| abstract |
A compound of formula 1′ n n n n n n n n n n wherein:n V is —CH 2 —, —NH—, or —O—; R a and R b are each independently hydrogen, C 1-4 -alkyl, or halogen-C 1-4 -alkyl, or R a and R b together are a C 2-5 -alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R 1 and R 1′ are each independently hydrogen, C 1-6 -alkyl, C 3-6 -cycloalkyl, halogen-C 1-6 -alkyl, halogen-C 3-6 -cycloalkyl, or C 1-6 -alkylene-C 3-6 -cycloalkyl, or R 1 and R 1′ together are a C 2-5 -alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R 2 , R 2′ , R 2″ , and R 2′″ are each independently hydrogen, C 1-6 -alkyl, halogen-C 1-6 -alkylene, OH, HO—C 1-6 -alkylene, —O—C 1-6 -alkyl, C 6-10 -aryl, C 6-10 -aryl-C 1-4 -alkylene, C 6-10 -aryl-C 1-6 -alkylene-O, COOH, COOC 1-6 -alkyl, O—C 1-6 -alkylene-COOH, O—C 1-6 -alkylene-COOC 1-6 -alkyl, NHSO 2 —C 1-6 -alkyl, CN, NH 2 , NH—C 1-6 -alkyl, N(C 1-6 -alkyl) 2 , NO 2 , S—C 1-6 -alkyl, SO 2 —C 1-6 -alkyl, SO—C 1-6 -alkyl, O(CO)C 1-6 -alkyl, COC 1-6 -alkyl, NHCOC 1-6 -alkyl, or halogen; and n is 0, 1, or 2,n nor an optical isomer thereof, or a corresponding acid addition salt thereof with a pharmacologically acceptable acid, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints. |