| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7e7bd367cc972b519b5aceca4720a12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_619a07bf430803a81b6704851ce1f763
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_775dcfc65142655e739b5076cef55863
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cbb44751bf6b4d6738b359075a1683d8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57492
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0693
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0695 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-095 |
| filingDate |
2007-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d3fe95d709e03e73f9f5d4610c2566b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9080ce8a85abaecb3db1cd897dc1e54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83e9eec78302968e75b5f497780aedbc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4d1241c93d7c49e5670161907295532 |
| publicationDate |
2008-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2008194022-A1 |
| titleOfInvention |
Isolation and use of solid tumor stem cells |
| abstract |
A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. n We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells. n We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8784811-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010111958-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8980260-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011195065-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8834875-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8921106-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8945873-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012012803-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9499613-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9505832-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8945874-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9617340-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9132189-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9676865-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8206713-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8226943-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11739366-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8404237-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8435513-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8425903-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8460661-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8945547-B2 |
| priorityDate |
2000-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |