Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1b0c198757da18cf77dfbdcef00abb70 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1024 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 |
filingDate |
2008-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abf56796d24f5ee7112e265c1bd64034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c13ba59aa584b12e83c6096562384a09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d77b8829439f70b8282a3f7766c56218 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56246ca85d36d9aa791bfc08c1722267 |
publicationDate |
2008-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2008193979-A1 |
titleOfInvention |
Method for generating diversity |
abstract |
The invention relates to a method for preparing an antibody-producing cell line capable of directed constitutive hypermutation of a specific nucleic acid region, comprising the steps of: a) screening a clonal cell population for V gene diversity; b) isolating one or more cells which display V gene diversity and comparing the rate of accumulation of mutations in the V genes and other genes of the selected cells; and c) selecting a cell in which the rate of V gene mutation exceeds that of other gene mutation. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8389235-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8679845-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010093033-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008227123-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9815885-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9273119-B2 |
priorityDate |
2001-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |