| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5bc5292a07e34d16eb1d033a16d3aec3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0041
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-01 |
| filingDate |
2007-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba9557b3942a21a63a75cfad9c57eded
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6839d8f77d992dbb45208b1ec7962b1e |
| publicationDate |
2008-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2008187998-A1 |
| titleOfInvention |
Sulfonamide-based oligomers and polymers for destabilization of biological membranes |
| abstract |
Oligomeric sulfonamides for use as endosomolytic reagents for transfection with polymeric or lipid-based vectors are described. A mixture of an oligomeric sulfonamide with a polymeric or lipid-based gene carrier and a nucleic acid results in a polyplex that exhibits 6-12-fold better gene expression than controls. A method of transfecting cells in vitro is carried out by contacting cultured mammalian cells with an effective amount of a polyplex. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010056844-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3252068-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113461577-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8821364-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9289625-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4089169-A1 |
| priorityDate |
2007-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |