http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008183447-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b7317808024e524eea40a6c5a5ad6a22 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H50-50 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06F17-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06N3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06G7-58 |
| filingDate | 2006-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56b4a230bea3b63583f080980647d2ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b158369f9f5b0df71b322cf864d17e7 |
| publicationDate | 2008-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2008183447-A1 |
| titleOfInvention | Automatic Input Function Estimation For Pharmacokinetic Modeling |
| abstract | This system ( 200 ), apparatus ( 300 ), and method ( 100 ) of the present invention provide an analytic way to solve the (input) estimation problem of pharmacokinetic modeling: estimating parameters of a kinetic model from a series of tracer (radioactively labeled imaging agent) activity measurements (e.g. by positron emission tomography). Since the model describes a biological process its parameters have a direct functional interpretation (e.g. hypoxia for the tracer FMISO) that can be of diagnostic value. The measurements represent the activity distribution in time and space in the form of a 4D data set d(t, x, y, z), t=1, . . . , T. The kinetic parameter estimation procedure ( 205 ) requires knowledge of the tracer input activity. This input activity can either be measured invasively or it can be estimated from the data in a preprocessing step. The estimation problem can be solved efficiently if the model and its input are described analytically. Typically parameterized functions (often sums of exponential terms) ( 204 ) are fitted to the averaged data over a region of interest (ROI) (e.g. an artery or the left ventricular blood pool) in order to obtain an analytical input representation. The input function representation (functional form) ( 204 ) and its initial parameter values ( 205 ) have to be selected/specified prior to the fitting procedure 206 ). The present invention thereby reduces the amount of manual interaction and operator dependence in the evaluation of dynamic procedures. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9179885-B2 |
| priorityDate | 2005-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID450173 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID409102167 |
Total number of triples: 18.