| abstract |
This invention is directed to a crystalline acid of a lipoxin A 4 analog of Formula (II): n n n n n n n n n n wherein:n R 1 is —O—, —S(O) t — (where t is 0, 1 or 2), or a straight or branched alkylene chain; and R 2 is aryl (optionally substituted by one or more substituents selected from alkyl, alkoxy, halo, haloalkyl and haloalkoxy) or aralkyl (optionally substituted by one or more substituents selected from f alkyl, alkoxy, halo, haloalkyl and haloalkoxy);n nand wherein the compound of Formula (II) is a single stereoisomer or any mixture of stereoisomers.n nn This crystalline acid is useful in treating disease-states characterized by inflammation, such as inflammatory and autoimmune disorders or pulmonary or respiratory tract inflammations in humans. Methods of preparing the crystalline acid are also described. |