| abstract |
Pharmaceutical foam compositions substantially free of ethanol and comprising pimecrolimus in a carrier vehicle comprising a mixture of oily solvents amounting to at least 40% of the total weight of the composition and consisting of: n i) hexylene glycol;n nii) optionally oleyl alcohol; andn niii) dimethylisosorbide and/or medium chain triglycerides;n nand additionally:n niv) when oleyl alcohol is absent, water in an amount of less than 25%;n nv) at least one consistency agent;n nvi) at least one preservative; andn nvii) at least one surfactant/emulgator; and propellant gas for foaming;n nand optionally further conventional excipients.n n They are indicated for use in the treatment of various skin, nail and mucosal diseases. |