| abstract |
The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity: n n n n n n n n n n and wherein the variables Y, R 4 , n, o, A, A 1 , A 2 , X, Z, R 1 , R 3 , R 2 , p, q and r are as defined in the specification. These compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, and wound healing |