http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008146780-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ab65588fdabecdc9f5cf9f2fd3a68a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a80e5d4eb1627630e89af9027b4f498f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_20719136675b928b3ad5d0a9818c3460 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1211 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-82 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00 |
filingDate | 2007-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bfae725f93969aaea899fb5af6b82bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3e8ffa92070eab1da2dc2c5d399f2d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc9395c59ce78db556ad4d789b0ea181 |
publicationDate | 2008-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-2008146780-A1 |
titleOfInvention | MN Gene and Protein |
abstract | Identified herein is the location of the MN protein binding site, and MN proteins/polypeptides that compete for attachment to vertebrate cells with immobilized MN protein. Such MN proteins/polypeptides prevent cell-cell adhesion and the formation of intercellular contacts. The MN protein binding site is a therapeutic target that can be blocked by organic or inorganic molecules, preferably organic molecules, more preferably proteins/polypeptides that specifically bind to that site. Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Vectors are provided that encode the variable domains of MN-specific antibodies and a flexible linker polypeptide separating those domains. Further vectors are disclosed that encode a cytotoxic protein/polypeptide operatively linked to the MN gene promoter, and which vectors preferably further encode a cytokine. The MN gene promoter is characterized, and the binding site for a repressor of MN transcription is disclosed. |
priorityDate | 1999-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 784.