| abstract |
Use of a compound of formula (I): n n nwherein: R 1 is phenyl optionally substituted by halogen, cyano, C 1-4 alkyl or C 1-4 haloalkyl; R 2 is hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl; and R 3 is a group having an NH or OH that has a calculated or measured pKa of 1.0 to 8.0; or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the treatment of osteoarthritis or osteoarthrosis. The invention also concerns the benzenesulfonate salt of N-{3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]-2-hydroxypropyl}-2,3-dihydro-2-oxo-4-(trifluoromethyl)-5-thiazolecarboxamide, a process for making it, and its use in therapy (for example in treating CCR3 mediated disease states). |