http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008107682-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2b22f938a3bad9a077ffeaa346b06d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8cabf2d285edd0bb379faf0d487105f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-522 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-098 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-554 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 |
| filingDate | 2006-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b3c9462ec77a887374613975650afbf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae473cf214e47f46c431a75d17dc9fa5 |
| publicationDate | 2008-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2008107682-A1 |
| titleOfInvention | Brucella melitensis mutants and methods |
| abstract | Certain attenuated mutants of Brucella , especially B. melitensis, B. abortus, B. suis and B. ovis , when administered to a human or animal trigger a protective immune response such that subsequent challenge with virulent Brucella of the same species does not result in disease or results in much less severe symptoms. Functional inactivation of galE, a virB gene or the operon (ORFs 1087-1090) comprising the gene encoding β-hexosaminidase (BMEI1087) and a lytic murein transglycosylase gene (BMEI1088). A specific example of the attenuated galE mutant which produces a protective immune response is B. melitensis GR024. The specific example of an inactivated ORF1087-1090 operon is B. melitensis GR026; it has an insertion mutation in the promoter region upstream of ORF 1090. Vaccination with live cells of either or both of these mutants results in a T cell response which protects the human or animal against challenge with virulent B. melitensis . Similar strategies for protective immunity using live attenuated mutants are useful for B. abortus, B. suis and B. ovis as well. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014165278-A1 |
| priorityDate | 2005-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 587.