| abstract |
This invention relates to method for intradermal, transdermal or transmucosal delivering a biologically active substance to a mammal in need thereof, which method comprises a step of co-administering to said mammal with the biologically active substance an effective amount of an absorption enhancer, which is water comprising from about 99.760 to about 10 99.999% of light isotopologue 1 H 2 16 0 and up to 100% of residual isotopologues 1 H 2 17 0, 1 H 2 18 0, 1 H 2 H 16 0, 1 H 2 H 17 0, 1 H 2 H 18 0, 2 H 2 16 0, 2 H 2 17 0, and 2 H 2 18 0. Such biologically active substance is selected from the group consisting of drugs, physiologically active peptides, physiologically active proteins, glycoproteins, nucleic acid, nutrients, vitamins, and minerals. |