http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008102465-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3873abaff397acbfffa1595a12cfef41 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2007-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cfa7e4039dc67644049b71249f3d63f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94b6a9dc48bd040e3584a48bc7c517da |
| publicationDate | 2008-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2008102465-A1 |
| titleOfInvention | Pthrp-based prediction and diagnosis of bone disease |
| abstract | The invention provides methods of diagnosing bone disease and/or a susceptibility thereto, in an individual. The method includes screening a biological sample obtained from the individual for one or more genetic indicators of bone disease in said PTHrP gene of the individual, and diagnosing the individual based on a characterization of the genetic indictor(s) detected. A genetic indicator of the invention preferably includes a genetic segment of a PTHrP gene. More preferably, a genetic segment of a PTHrP gene includes a VNTR containing region. The invention further relates to transgenic non-human mammals for the study of bone disease and/or bone conditions or for drug discovery, lead optimization, identification of drug candidates & drug development, wherein a transgenic mammal of the invention may be (a) homozygous for disrupted PTHrP gene only in osteoblast cells of said mammal (PTHrPflox/flox crecol I); (b) heterozygous for disrupted PTHrP gene (PTHrP −/+ ) in all cells of said mammal; or (c) heterozygous for disrupted PTHrP gene (PTHrP −/+ ) only in osteoblast cells of said mammal. |
| priorityDate | 2002-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 192.