| abstract |
Compounds that may be used for the treatment or prevention of a condition associated with T-cell proliferation or that is mediated by pro-inflammatory cytokines are of formula (I): n n nwherein R 1 is CHR 4 —OR 5 or CHR 4 —SR 5 , or aryl or heteroaryl optionally substituted with one or more groups R 6 ; R 2 is alkyl or is part of a ring with R 3 ; R 3 is H, alkyl or CH 2 (when forming part of a ring with R 2 ); R 4 is H or alkyl or is part of a ring with R 5 ; R 5 is aryl or heteroaryl optionally substituted with R 7 ; each R 6 is independently alkyl, CF 3 , OH, Oalkyl, OCOalkyl, CONH 2 , CN, halogen, NH 2 , NO 2 , NHCHO, NHCONH 2 , NHSO 2 alkyl, CONH 2 , SOMe, SO 2 NH 2 , Salkyl, CH 2 SO 2 alkyl or OCONalkyl 2 ; R 7 is R 8 or (CH 2 ) n OR 8 , R 9 , CF 3 , OH, OR 9 , OCOR 9 , COR 9 , COOR 9 , CONH 2 , CH 2 CONH 2 , CN, halogen, NH 2 , NO 2 , NHCHO, NHCONH 2 , NHCONHR 7 , NHCON(R 9 ) 2 , NHCOR 9 , NHCOaryl, NHSO 2 Me, CONH 2 , SMe, SOMe Or SO 2 NH 2 ; R 8 is (CH 2 ) n OR 9 , (CH 2 ) n OR 9 , (CH 2 ) n COOR 9 or (CH 2 ) n COaryl; R 9 is alkyl or cycloalkyl; and n is 1 to 4; or a salt thereof. |