| abstract |
Compounds of formula (I) below are disclosed. Their use as medicaments is described, in particular for the treatment of pain or inflammation: n nwherein: n nwhen X═Y=Z=OH, R 1 is OCH 2 CF 2 CF 3 , phenoxy (substituted with 3-(4-trifluoromethylphenyl), 3,4-dichloro, (3-trifluoromethyl,4-fluoro), (3-trifluoromethyl,4-chloro), (3-chloro, 4-cyano), or 3,5-bis(trifluoromethyl)), 1-piperazinyl(4-(3,4-dichlorophenyl)), phenyl (substituted with 3,4-dichloro, 3,5-difluoro, 3,5-bis(trifluoromethyl) or 3,4,5-trifluoro) or 2-benzofuranyl; or n nwhen X═Y═OH and Z=OMe, R 1 is OCH 3 , OCH 2 CHF 2 , OCH 2 cyclopentyl, O-(2,5-difluorophenyl) or (S)-sec-butylamino; or n nwhen X═H and Y=Z=OH, R 1 is n-hexylamino or cyclopentylamino; or n nwhen (IV) X=Z=OH and Y═H, R 1 is cyclopentylamino; nor a pharmaceutically acceptable salt thereof. |