| abstract |
The invention relates to N-phenylphosphonic acid triamides of general formula (I), to a method for the production thereof and to their use as agents for regulating or inhibiting enzymatic urea hydrolysis. In formula (I), X represents oxygen or sulfur; R 1 , R 2 , R 3 , R 4 , R 5 , independent of one another, represent hydrogen C 1 -C 8 alkyl/heteroalkyl, C 2 -C 8 alkenyl/heteroalkenyl, C 2 -C 8 -alkynyl/heteroalkynyl, C 3 -C 8 cycloalkyl/heterocycloalkyl, C 3 -C 8 cycloalkenyl/heterocycloalkenyl, C 6 -C 10 aryl/C 5 -C 10 heteroaryl, aralkyl, heteroarylalkyl, alkaryl, alkheteroaryl, alkoxy, aryloxy, hetaryloxy, alkylthio, arylthio, hetarylthio, acyl, aroyl, hetaroyl, acyloxy, aroyloxy, hetaroyloxy, alkoxycarbonyl, aryloxycarbonyl, hetaryloxycarbonyl, alkylsulfonyl, fluorine, chlorine, bromine, iodine, cyano, nitro, sulfo, carbonyl, carboxy, carbamoyl, sulfamoyl, with the provision that: at least one radical R is not hydrogen; in the event R 1 , R 2 , R 4 , R 5 represent H, R 3 is not nitro or cyano, and; in the event R 1 represents Cl or R 1 and R 3 represent Cl, at least one of the remaining radicals is not hydrogen. |