http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008070853-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ebc6a4286c4c7ef3a3d96ccf785430c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aafd2b0a6341bcda19ca9bdd4859a972 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03bc488c20e5387a84b50db4bd808af1 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4746 |
classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 |
filingDate | 2004-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1981e6323b55285811362e32f9f7a986 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d94f4acd84f038be6d52866d4456a1b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2374030cdc9a0413488ce7ea4e7f46e0 |
publicationDate | 2008-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-2008070853-A1 |
titleOfInvention | Peptides Selectively Lethal to Malignant and Transformed Mammalian Cells |
abstract | The present invention provides peptides corresponding to all or a portion of amino acid residues 12-26 of human p53 protein, which peptides are lethal to malignant or transformed cells when fused to a membrane-penetrating leader sequence. The subject peptides are thus useful in treating neoplastic disease in an animal, preferably a human. Also provided are pharmaceutical compositions comprising the subject peptides admixed with a pharmaceutical acceptable carrier. Methods of treating neoplastic disease in a patient by administering a subject peptide fused at its carboxy terminal end to a membrane penetrating leader sequence are also provided. The present invention also provides replication incompetent Adenovirus (AdV) vectors comprising a promoter sequence operably linked to a nucleotide sequence encoding a subject peptide. Methods of selectively killing cancer cells in a subject by administering a therapeutically effective amount of a subject AdV vector are also provided by the present invention. |
priorityDate | 2000-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 640.