| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a722744e77c81c5f5cf415087e2ee92b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e7aa001f3235c07b0298867908d45e21 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2821 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-06 |
| filingDate |
2007-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b03b91949083fff5e17d4877d73d5552
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_246e746667a000a0f6cc3a95298d7bc9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a01d9c1a60b19bd8b8f6b268e79ee629
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_883144bde0171b8de61268dae000e37c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df11c46baa4cd0c7b6b7b64c9945b99c |
| publicationDate |
2008-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2008058276-A1 |
| titleOfInvention |
Alzheimer's disease therapeutics based on pin-1 catalyzed conformational changes in phosphorylated amyloid precursor protein |
| abstract |
The present invention is directed to inhibiting amyloidogenic processing of amyloid precursor protein, and/or inhibiting production of amyloid beta peptides. These methods can involve accelerating cis/trans isomerization of amyloid precursor protein at a phosphorylated serine/threonine-proline motif and/or contacting a cell with a compound that mimics the cis conformation of a phosphorylated serine/threonine-proline motif of an amyloid precursor protein. The present invention also relates to treating and/or preventing in a subject a degenerative neurological disease characterized by amyloidogenic processing of amyloid precursor protein and/or overproduction of amyloid beta peptide. This method involves administering an agent that accelerates cis/trans isomerization of amyloid precursor protein at a phosphorylated serine/threonine-proline motif and/or inhibits production of amyloid β peptides. Methods of screening for therapeutic agents effective in treating and/or preventing such diseases, methods of screening for biological molecules involved in the amyloidogenic pathway, and compounds that mimic the cis conformation of a phosphorylated serine/threonine-proline motif of an amyloid precursor protein are also disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9822171-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9062101-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10487114-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9796784-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8497072-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8455626-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9359430-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005282740-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10047121-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113621078-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106503487-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8877190-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009191190-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011056561-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9951125-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9540432-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10464976-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8895004-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10208109-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10323084-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8691224-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8771693-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009035307-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009238831-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9394360-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012149334-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9176150-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10538581-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012149334-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014152157-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8987419-B2 |
| priorityDate |
2006-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |