| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c4322cb4de342be2dbedcbe0c278f6f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-96
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0046 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-96
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0012
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0046
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-96
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
2007-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0af1ed3add5c44168de01d23db7b750e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4f7d585fc569a0697dc6ce1ae084368
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9e0a60d1a6d4f22d6088abc101f6131
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_581c8bdf85e33e0a3d71b9159b9c90f5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d701f486164965fa4ab57c54896a805 |
| publicationDate |
2008-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2008057048-A1 |
| titleOfInvention |
Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| abstract |
A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10160958-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11639927-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010323423-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8921064-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010323422-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8067553-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11781119-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008031864-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11598767-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7927589-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10139399-B2 |
| priorityDate |
1998-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |