abstract |
Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: n n nincluding steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: n n nand wherein R 1 , R 2 , R 3 , X, Z, L 1 , Cycl 1 , L 2 and Cycl 2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof. |