| abstract |
The present invention includes methods and compositions for reducing cyst formation in a patient with polycystic kidney disease by contacting the kidney of the patient with an effective amount of a fibrocystin cleavage inhibitor sufficient to reduce cyst formation, wherein the fibrocystin cleavage inhibitor comprises at least one of a proteasome inhibitor, a calpain inhibitor, and a β-secretase inhibitor and reduces the degradation of the fibrocystin cleavage products. |