| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-735
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2795-14122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2795-14022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-00011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S930-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S436-802 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6845
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1037
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-575 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-554
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2007-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2bb32e9ccb1e8ea3d937a57c1af01aec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43c8edceee5a00a9081d0e2b62acfa81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_655858c4f55f2e063b09d6681828fe70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_add5b1f81ff0a96f3ffd767c10364b9a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5396f8854503748447bb30b135165b6d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a7adc43508999f75c04bd3ca2f72593
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d89782c199f6566e4b09c0f2bb0f0398 |
| publicationDate |
2008-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2008038717-A1 |
| titleOfInvention |
Enrichment method for variant proteins with altered binding properties |
| abstract |
A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disclosed are preferred phagemid expression vectors and selected human growth hormone variants. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10457727-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007237764-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10221236-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10227402-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7998930-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7884073-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10344083-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8679490-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8911734-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11214610-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9783601-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9783602-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9078878-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9718882-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9738713-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9067988-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9884909-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9539324-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8222209-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008194477-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8937159-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011177095-A1 |
| priorityDate |
1990-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |