| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b7edd3693b55c0fd41df267c299f173
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3da168962c8dbb03e022f08e6ec72ac7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_09bd9b29160d3ade2928e67da93e8ee9 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-117 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2007-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4eb4c9e9e50fd8420149c33ac759a15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3f6b8bb1ef0370affbd97554a533998
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e230d18fe89aa8398b7cdc673d169626 |
| publicationDate |
2008-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2008026986-A1 |
| titleOfInvention |
Reversal of the suppressive function of specific t cells via toll-like receptor 8 signaling |
| abstract |
CD8 + regulatory T (Treg) cells and γδ Treg cells profoundly suppress host immune responses and thus protect against autoimmune disease while restricting desired immune responses such as antitumor immunity. Synthetic phosphorothioate-protected, guanosine-containing oligonucleotides can directly reverse the suppressive activity of Treg cells without involving dendritic cells. This effect appears to be transduced by signaling through Toll-like receptor (TLR) 8 and engagement of the MyD88 and IRAK4 molecules in Treg cells, in specific embodiments. Stimulation of Treg cells with natural ligands for human TLR8 recapitulated the effect of the synthetic guanosine-containing oligonucleotides. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010042530-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11135245-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9228184-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011229560-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2756247-C2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10346973-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016081518-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009209620-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010042530-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11299708-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9868955-B2 |
| priorityDate |
2006-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |