http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008026461-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7a3886f1cdaa7211491a8f2de9831c4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1323 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-094 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0697 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0698 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate | 2007-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ad89987801c145f42ed18f32d5c8521 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29779004f9a165edcffc0403f8dbed1d |
| publicationDate | 2008-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2008026461-A1 |
| titleOfInvention | Tissue-like organization of cells and macroscopic tissue-like constructs, generated by macromass culture of cells and the method of macromass culture |
| abstract | Three-dimensional tissue-like organization of cells by high cell-seeding-density culture termed as macromass culture is described. By macromass culture, cells can be made to organize themselves into a tissue-like form without the aid of a scaffold and three-dimensional macroscopic tissue-like constructs can be made wholly from cells. Tissue-like organization and macroscopic tissue-like constructs can be generated from fibroblastic cells of mesenchymal origin (at least), which can be either differentiated cells or multipotent adult stem cells. In this work, tissue-like organization and macroscopic tissue-like constructs have been generated from dermal fibroblasts, adipose stromal cells-derived osteogenic cells, chondrocytes, and from osteoblasts. The factor causing macroscopic tissue formation is large scale culture at high cell seeding density per unit area or three-dimensional space, that is, macromass culture done on a large scale. No scaffold or extraneous matrix is used for tissue generation, the tissues are of completely cellular origin. No other agents (except high cell-seeding-density) that aid in tissue formation such as tissue-inducing chemicals, tissue-inducing growth factors, substratum with special properties, rotational culture, etc, are employed for tissue formation. These tissue-like masses have the potential for use as tissue replacements in the human body. Tissue-like organization by high cell-seeding-density macromass culture can also be generated at the microscopic level. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9352003-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11191788-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10092600-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10912864-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11305035-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11779610-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11524093-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11052175-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11596517-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8883210-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10531957-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8834928-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10130736-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10596201-B2 |
| priorityDate | 2002-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 274.