| abstract |
Compounds are provided which are glucokinase activators and thus are useful in treating diabetes and related diseases and have the structure n nwherein n in the ring represents one or two double bonds; R 1 is aryl or heteroaryl; R 2 is halogen, cycloalkyl, heterocyclyl, aryl, or heteroaryl; R 5 is as defined herein; Z is O, S, S(O), S(O)2, or NR 5a ; X is S, O, N, NR 3 , or CR 3 ; Y is NCR 4 or N 4 ; R 3 , R 4 , and R 5 are as defined herein; R 8 is aryl or heteroaryl; R 6 and R 7 are independently H, halogen, or alkyl; m is 0 or 1; and n is 0 to 3, or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided. |