http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008014187-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_21c79f1d7260da495f22f293797299c1 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-401 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-191 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-204 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-554 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-554 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-401 |
| filingDate | 2006-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4ae71c7be93baef0a816fde9349079d |
| publicationDate | 2008-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2008014187-A1 |
| titleOfInvention | Compositions and Methods for Treating Hypertension and Inflammation |
| abstract | The present invention relates to pharmaceutical compositions for reducing essential hypertension and systemic inflammation. While many drugs have been found to treat hypertension, the currently available drugs often do not maintain reduced blood pressure at the preferred norm of 115/75 mm Hg or less throughout a 24 hour period. The current invention provides compositions comprising at least one hypertensive drug combined with the natural product Coenzyme Q10 (ubiquinone or CoQ10), which synergizes with the antihypertensive drugs to maintain low blood pressure throughout the day and night while generating other positive effects on the risks of cardiovascular disease, renal failure, and stroke. CoQ10 also counteracts some of the side effects of some hypertensive drugs such as tiredness, weakness, and/or liver toxicity. The invention further describes therapeutically effective methods for reducing systemic inflammation in hypertensive mammals comprising treatment with an antihypertensive composition that includes at least one angiotensin-converting enzyme inhibitor or angiotensin receptor blocker and CoQ10 (ubiquinone). The invention metrics for reducing systemic inflammation comprise the reduction of serum levels of high sensitivity C-reactive protein (CRP), Interleukin 6 (IL-6), and/or tumor necrosis factor-alpha (TNF-alpha). These antihypertensive-CoQ10 combinations will synergistically reduce both hypertension and systemic inflammation. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11028446-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10376477-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9901542-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10351915-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10959938-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102483419-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11452699-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10519504-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11298313-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015320703-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10933032-B2 |
| priorityDate | 2006-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 406.