Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_de35f25aef466af2b42b3eeb92bb4bdc |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-422 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 |
filingDate |
2007-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcd976f6bfb54881a15c819100d0b471 |
publicationDate |
2007-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2007293552-A1 |
titleOfInvention |
Antihypertensive therapy method |
abstract |
Methods and therapeutic combinations are provided for lowering blood pressure in a subject exhibiting resistance to a baseline antihypertensive therapy with one or more drugs, or a subject having diabetes and/or chronic kidney disease. A method of the invention comprises administering, in some embodiments adjunctively with a modified baseline therapy, a compound of formula (I) as defined herein. A therapeutic combination of the invention comprises a compound of formula (I); at least one diuretic; and at least one antihypertensive drug selected from ACE inhibitors, angiotensin II receptor blockers, beta-adrenergic receptor blockers and calcium channel blockers; wherein the at least one diuretic and/or the at least one antihypertensive drug are present at substantially less than a full dose. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020021341-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013049697-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2700563-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9988422-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106913860-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11478462-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11420998-B2 |
priorityDate |
2006-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |