| abstract |
A medicament having inhibitory activity against plasminogen activator inhibitor-1, which comprises as an active ingredient a compound represented by the following general formula (I) or a salt thereof: n n nwherein R 1 and R 2 represents an aromatic group which may be substituted, W represents a group selected from the following connecting group W-1: n n(wherein a bond at the left end binds to the carbon atom and a bond at the right end binds to the nitrogen atom, X represents sulfur atom or NH, Y represents oxygen atom or sulfur atom, n nR 3 represents a hydrocarbon group, hydroxy group, or carboxy group), nZ represents a single bond or a connecting group wherein a number of atoms in a main chain is 1 to 3. |