| abstract |
Compounds of formula (IA) or (AB) are kinase inhibitors, especially of CDK2, and/or PDK1 and/or CHK1: wherein Ring A is an optionally substituted aryl, heteroaryl, carbocyclic or heterocyclic radical, Alk represents an optionally substituted clivaient C 1 -C 6 alkylene radical; n is 0 or 1; Q represents a radical of formula -(Alk 1 )p-(X),(Alk 2 ) s -Z wherein in any compatible combination Z is hydrogen or an optionally substituted carbocyclic or heterocyclic ring, p, r and s are 0 or 1, and Alk 1 , Alk 2 , X, are as described in the specification, and R 1 represents a radical 3 4 3 (CYC) k -(Alk 3 ) a -(Y) b -(Alk 4 ) d -B wherein k, a, b and d are 0 or 1, and Cyc, Alk 3 , Alk 4 and B are as described in the specification. |