| abstract |
Derivatives of pyrrolo[2,1-b]benzothiazepines with formula (I) where A is CH—CH 2 C═CH; R is hydrogen, halogen, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, C 1 -C 4 alkyl, C 5 -C 6 cycloalkyl; R 1 is 1-peperazinyl, 1-homopiperazinyl and 1-piperidinyl; R 2 is hydrogen, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, C 1 -C 4 alkyl, CHO, CH═NOH,CH 2 OH. The formula (I) compounds are endowed with characteristic atypical anti-psychotic activity, and are therefore useful as medicaments, in particular for the treatment and prevention of schizophrenia, paranoid states, manic-depressive states, disorders of the affective sphere, social regression, personality regression, and hallucinations. Said compounds also present advantageous pharmacokinetic properties. |