| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_006e91eddabe95ad7aa889123d31cb9a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
2007-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccec9352d29b5d77d16a26320335df6a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22dac908a3adce66883605cc5c1b3fa9 |
| publicationDate |
2007-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2007269447-A1 |
| titleOfInvention |
Cytotoxic agents comprising new maytansinoids |
| abstract |
New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the α-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new maytansinoids to cell-binding agents. The maytansinoid-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107537040-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9072798-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010129314-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2486023-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9150649-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9283276-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2486023-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014114207-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022010797-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9090693-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10960082-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104974252-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9023356-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011100403-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9562102-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016192527-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017088734-A1 |
| priorityDate |
2003-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |