| abstract |
The present invention relates to a compound of formula (I) n n na N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein R 1 represents hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, C 1-6 alkyloxyC 1-6 alkyl, di(C 1-6 alkyl)aminoC 1-6 alkyl, aryl or heteroaryl; each R 2 independently represents halo, C 1-6 alkyl, C 1-6 alkyloxy, C 1-6 alkylthio, polyhaloC 1-6 alkyl, polyhaloC 1-6 alkyloxy, cyano, aminocarbonyl, amino, mono- or di(C 1-4 alkyl) amino, nitro, aryl or aryloxy; R 3 represents hydrogen, cyano, optionally substituted C 1-6 alkyl, C(═O)—O—R 5 , C(═O)—NR 6a R 6b , C(═S)—NR 6a R 6b , S(═O) 2 —NR 6a R 6b or C(═O)—R 7 ; R 4 represents hydrogen or C 1-6 alkyl; n is 1, 2, 3, 4 or 5; Z represents a cyclic ring system. The invention also relates to processes for preparing the compounds of formula (I), their use as CCR2 antagonists and pharmaceutical compositions comprising them. |