| abstract |
Monocyclic and bicyclic himbacine derivatives of the formula n n n n n n n n n n or a pharmaceutically acceptable salt or solvate of said compound whereinn represents an optional double bond and wherein G n , J n , R 3 , R 8 , R 9 , R 10 , R 11 , R 32 , R 33 , B and Het are herein defined are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other agents is also claimed. |