| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_879d32a53b3ec7161fd0d966b0b48b19 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-4858 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-66 |
| filingDate |
2007-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94c42bb8f5d3a8d49d4b6f54c0eeaafe |
| publicationDate |
2007-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2007224261-A1 |
| titleOfInvention |
Eutectic liquid drug formulation |
| abstract |
A drug formulation dosage is provided that includes an oral medication capsule inclusive of the eutectic liquid at room temperature. The eutectic liquid includes a pharmaceutically active substance that exists as a solid in pure form at room temperature along with a biologically tolerated compound that forms a eutectic liquid with the active substance so as to render the substance and the compound as the eutectic liquid. The resulting drug formulation dosage has a high degree of storage stability. Natural volatile oils represent a class of biologically tolerated compounds well suited for the formation of a eutectic liquid sealed within an oral medication capsule. Three or more component eutectics are also appreciated to be operative herein to form stable eutectic liquids with pharmaceutically active substances. A process for delivering a pharmaceutically active substance existing at room temperature in pure form as a solid as an oral dosage includes administering to a subject orally a pharmaceutically effective amount of the substance as a eutectic liquid formed with the biologically tolerated natural volatile oil. The eutectic liquid is contained within a capsule disintegrating subsequent to administration to the subject and thereby releasing the pharmaceutically active substance. A transdermal medicament delivery system is also provided that includes multiple small capsules of a drug formulation dosage as detailed above. The integrity of the capsule is compromised after exposure to subject skin through temperature, perspiration dissolution or concussion. A skin compatible adhesive matrix retains the multiple drug formulation dosage capsules in contact with subject skin so as to release the active substance into contact with subject skin. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010249080-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011014850-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113164392-A
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9832993-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009071422-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2008333435-B2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017055555-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NL-2023661-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8501743-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9084754-B2 |
| priorityDate |
2006-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |