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filingDate 2006-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8861c8b8b7e332c3dcc5ab75f9ff064e
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publicationDate 2007-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2007219162-A1
titleOfInvention Partially-fluorinated ethers, compositions and uses thereof, for long-term tamponade in the eye
abstract The present invention provides a single high-purity liquid comprising a partially fluorinated ether liquid for use as a long-term tamponade agent. Compositions are directed to liquid tamponade agents consisting essentially of DFPE, or to agents comprising a soluble mixture of a partially fluorinated ether and either a silicone liquid (or oil) or a perfluorocarbon liquid (or any other liquid or oil that is clear, colorless, inert and has a low specific gravity). Partially fluorinated ethers that have a specific gravity between 1.1 and 1.5 are well suited to rectify the deficiencies of silicone and perfluorocarbon liquids when they are used as tamponade agents. The soluble mixtures of the invention can be designed to have a specific gravity so that they do not have buoyancy problems (density greater than water), yet having a specific gravity that is not so high as to damage the posterior retina from mechanical forces (specific gravity less than 1.6). The mixtures can also be designed to have a specific gravity such that the mixture can act as a tamponade on both the superior and inferior retina simultaneously. The present invention provides such soluble mixtures and also partially fluorinated ether liquids alone, for the use and for the method of postoperative tamponade. Thus, partially fluorinated ether liquids, and mixtures thereof, can be left in the eye postoperatively due to their long-term compatibility with the eye, thereby improving the success of retinal reattachment and healing procedures.
priorityDate 2004-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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