| abstract |
Disclosed are methods for lowering cholesterol and treating heart disease in an animal employing prenylchalcones or prenylflavonones. Such prenylchalcones or prenylflavonones may be derived from hops ( humulus Lupulus L .), or produced synthetically. Representative prenylchalcones or prenylflavonones are: xanthohumol, xanthogalenol, desmethylxanthohumol (2′,4′,6′,4-tetrahydrooxy-3-C-prenylchalcone), 2′,4′,6′,4-tetrahydrooxy-3′-C-geranylchalcone, dehydrocycloxanthohumol, dehydrocycloxanthohumol hydrate, 5′-prenylxanthohumol, tetrahydroxanthohumol, 4′-O-5′-C-diprenylxanthohumol, chalconaringenin, isoxanthohumol, 6-prenylnaringenin, 8-prenylnaringenin, 6,8-diprenylnaringenin, 4′,6′-dimethoxy-2′,4-dihydroxychalcone, 4′-O-methylxanthohumol, 6-geranylnaringenin, 8-geranylnaringenin. The preferred prenylchalcone is xanthohumol |