| abstract |
The invention provides compounds of the formula (I) or a salt, solvate or N-oxide thereof, wherein: R 1 and R 2 are the same or different and each is selected from hydrogen, saturated C 1-3 hydrocarbyl, halogen and cyano; X is selected from C═O, C═S, C(═O)NH, C(═S)NH, C(═O)O, C(═O)S, C(═S)O and C(═S)S; R 3 is selected from aryl and heteroaryl groups each having from 5 to 12 ring members and being unsubstituted or substituted by one or more substituent groups R 10 as defined in the claims; R 4 and R 5 are the same or different and are selected from hydrogen and methyl; or one of R 4 and R 5 is selected from hydroxymethyl and ethyl and the other is hydrogen; and R 6 and R 7 are the same or different and are selected from hydrogen and methyl. The compounds of the formula (I) hayed activity as p38 MAP kinase and Taf kinase inhibitors. |