| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96eddd31165955882708d73c89118259 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D225-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-397
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-02 |
| filingDate |
2007-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6daf553920da911f716fcd72c7a1a758
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e390c10853d5b9794df69f0260128a1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f4cec401274f59426b0b15594a9e269
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76643ac68c2c7699aca815e97b3cfd62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0def72351064f280875da8788bb3a1fa |
| publicationDate |
2007-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2007207992-A1 |
| titleOfInvention |
Geldanamycin derivatives and method of use thereof |
| abstract |
The present invention relates to novel geldanamycin derivatives which have antitumor and antiparasitic properties. The geldanamycin derivatives disclosed herein have antitumor properties in humans due to their interaction with human heat shock protein 90 (hsp90). The human parasites Plasmodium falciparum, Trypanosoma Cruzi , and Leishmania donovani are lethally susceptible to exposure to geldanamycin via complexation of geldanamycin with their homologs (Pfhsp90, hsp83, and hsp90, respectively) of the human hsp90. The geldanamycin derivatives disclosed herein also interact with these parasitic hsp90 homologs so as to have antiparasitic properties. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3552664-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102127019-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020006269-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020006296-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012154967-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011154895-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013112706-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011154895-A3 |
| priorityDate |
2006-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |