| abstract |
The invention relates to triptolide derivatives of Formula (I), their pharmaceutically acceptable salts and optical isomers, Formula (I): n n n wherein, C5 and C6 connect with each other by a C—C single bond or double bond; when C5 and C6 are connected with C—C single bond, X and Y represents independently hydrogen, oxygen, hydroxyl, halogen, lower alkyl-oxy, lower alkyl-amino, mercapto, lower alkyl-thio, the group of formula —OCOR, —OSO 2 R or —OPO(OH) 2 , each of which is attached to C5 and C6, R represents —(CH 2 )nCO 2 Na, —(CO 2 )nCO 2 K, or —(CH 2 )nCH 3 , wherein n=1-6; Z represents hydrogen, oxygen, hydroxyl, halogen, lower alkyl-oxy, lower alkyl-amino, mercapto, lower alkyl-thio, the group of formula —OCOR, —OSO 2 R or —OPO(OH)2, each of which is linked at C14-position, R represents —(CH2)nCO2Na, —(CO 2 )nCO 2 K, or —(CH 2 )nCH 2 , wherein n=1-6; wherein, the “_” linked with X, Y, and Z represents “ ” or “ ”, but X and Y cannot both be hydrogen atom at the same time, the methods for preparing them and their use as antiphlogistic agent, immunosuppressive agent or therapeutic agent for other related diseases. |