Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8dbdc6b42fa8eb41cba195e673df3922 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9015 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-18 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B50-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00 |
filingDate |
2004-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbc4b2d8e0abffeb89fe005875f8c07a |
publicationDate |
2007-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2007178456-A1 |
titleOfInvention |
Targeting enzymes of the trna splicing pathway for identification of anti-fungal and/or anti-proliferative molecules |
abstract |
The present invention relates to a method for screening and identifying compounds that modulate the activity of one or more components in the tRNA splicing pathway. In particular the invention relates to a method for screening and identifying compounds that modulate the activity tRNA splicing endonuclease and/or tRNA splicing ligase. The invention provides assays for the identification of compounds that inhibit animalia tRNA splicing endonuclease and/or animalia tRNA splicing ligase. The invention also provides assays for the identification of compounds that inhibit fungal tRNA splicing endonuclease and/or fungal tRNA splicing ligase. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads useful for treating and/or preventing cancer and/or fungal infections. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010267035-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007178067-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007056560-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10150987-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007056560-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9890416-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7829503-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005053985-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7939468-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8278085-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017096701-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006269923-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010136710-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007020630-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011044238-A1 |
priorityDate |
2003-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |