http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007178124-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56b349c10a8bb7f142a2d3de830114a5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-112 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-204 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L24-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0024 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L24-0015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate | 2007-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33d75ad28efc3e9877ededcf2e607544 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4d0eaf41551a723a8cbc68ee4209692 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cfbe654d4e389615f2a9532f3d1bec0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c22d3c08bf222b63bf75c75b206827d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff7fe26b39e02a733111779a58e58226 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21d97762a15c055346ec13a28394d076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa6b6abbd52f334d59f4c001bae83ca2 |
| publicationDate | 2007-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2007178124-A1 |
| titleOfInvention | Inorganic phosphates reversibly grafted with bioactive compounds and a method of their preparation |
| abstract | Biologically active solid systems are disclosed, containing immobilized organic compounds, such as medicines, in the form of materials appropriate as bone fillers, implant coatings or other alike systems, of the common formula B—P-A, where B is an inorganic support consisting of calcium phosphate, calcium hydroxyphosphate (hydroxyapatite), their mixture, or some other biocompatible mixture containing these or other insoluble inorganic phosphates, —P— is a phosphoryl group —P—O—, and A is the residue of the immobilized, organic, biologically active compound, such as a medicine, containing unprotonated amine and/or hydroxide group(s), and a method of their preparation consisting of the treatment of inorganic phosphate with a grafting reagent and consequent reaction with organic compound. As a grafting reagent, phosphorus pentachloride is applied and all operations are completed in an aprotic solvent. The advantage of the above product is the extension of the time duration of release of the immobilized organic compound such as a medicine from the surface, the release of the organic compound in its initial, unaltered, fully biologically active form, in the absence of any toxic or alien side products of hydrolytic decomposition of the immobilized system. |
| priorityDate | 2006-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.