| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8c0982b0f02b1ed6d20a315370a3a3a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K9-008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-14 |
| filingDate |
2007-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbd7c5642c47bff82bff2e229466d394 |
| publicationDate |
2007-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2007173438-A1 |
| titleOfInvention |
[PSI[CH2NH]PG4] glycopeptide antibiotic analogs |
| abstract |
[ψ[CH 2 NH]PG 4 ] glycopeptide antibiotic analogs are reengineered forms of glycopeptides that exhibit antimicrobial activity against both wild type and glycopeptide antibiotic resistant strains of microorganisms. For example, [ψ[CH 2 NH]Tpg 4 ] vancomycin aglycon is a reengineered form of vancomycin that exhibits antimicrobial activity (MIC=31 μg/mL) against both wild type and VanA resistant organism ( E. faecalis BM4166). The VanA resistant organism achieves its resistance, upon glycopeptide antibiotic challenge, by remodeling its D-Ala-D-Ala peptidoglycan cell wall precursor to D-Ala-D-Lac. [ψ[CH 2 NH]PG 4 ] glycopeptide antibiotic analogs have an altered glycopeptide backbone wherein the carbonyl of the fourth amino acid residue of the glycopeptide backbone has been replaced with a methylene. This alteration of the glycopeptide backbone imparts dual binding affinities for both D-Ala-D-Ala and D-Ala-D-Lac and dual antimicrobial activities for both wild type and resistant strains. For example, [ψ[CH 2 NH]Tpg 4 ]vancomycin aglycon displays a antimicrobial potency that reflects its altered binding characteristics. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017521432-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10577395-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11690859-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011046041-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10201587-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9879049-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111635262-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017152291-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014521695-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2278989-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2278989-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2015287695-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013022763-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11311562-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11179406-B2 |
| priorityDate |
2006-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |