| abstract |
An isolated polypeptide comprising a sequence that includes X −5 -X −4 -X −3 -X −2 -X −1 -X +1 , wherein X −5 is Arg, Ala, Ser, or Glu; X −4 is Leu; X −3 is Lys, Ala, Gln, or Asn; X −2 is Gly or Ala; X −1 is Gly; and X +1 is Ala, Gly, Asn, Val, or Lys; and the polypeptide, upon contact with SARS-CoV PLP2, murine hepatitis virus PLP, or bovine coronavirus PLP, is cleaved between residues X −1 and X +1 Also disclosed are related nucleic acids, vectors, host cells, screening methods, and treatment methods. |