| abstract |
The use of a compound of Formula ( 1 ): wherein for example: X and Y are independently selected from: oxygen, sulphur and (—CR a R b —) n ; wherein: n is an integer of from 1 to 4 and R a and R b are each independently selected from hydrogen, C 1-6 altkyl, C 1-6 alkoxy, halo, hydroxy, C 1-6 alkanoyloxy, C 3-12 cycloalkyl and optionally substituted phenyl or R a and R b together form a C 5-12 spirocycloalkyl or a carbonyl; R 1 and R 3 are independently selected from (a) optionally substituted phenyl or phenoxy; (b) optionally substituted naphth-1-yl or naphth-2-yl; (c) arylC 1-6 alkyl; (d) C 1-20 alkyl or C 1-20 alkenyl; and (e) adamantyl or a C 3-12 cycloalkyl R 2 is hydrogen, a C 1-8 alkyl or benzyl; or pharmaceutically acceptable salt, pro-drug or solvate thereof as DGAT inhibitors and in the manufacture of a medicament for the treatment of type II diabetes and/or obesity. |