http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007149581-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1dd98ad4ee076841fec541542f952f58 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 |
| filingDate | 2006-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99c4cd5fb95e02525b5f122b5aa5a4a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8e3a851e89dd848fc95f6efc9d48c35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6e5aa0761c31bb1e4cc84da1de72d09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba348ccec00e7743da199c749a85ceb3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb072186c38dfad701d53ccf1c35d43d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57b77877d40ebb4710b69c9d4e96d8d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc79b168ae52d5ff0f3d67eac59d14ca |
| publicationDate | 2007-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2007149581-A1 |
| titleOfInvention | Potent immunosuppressive agents derivatives and use |
| abstract | Provided herein include compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of the C3-amino and C5-methyl groups, also referred to as desmethyl, desamino-pateamine A. Suitable analogs provide anticancer and antiproliferative effects in vivo and in vitro by a novel drugs mechanism of action described herein for pateamine A, including inhibition of eIF4A-dependent translation initiation. As with pateamine A, as described herein, suitable analogs cause cell cycle arrest or induce apoptosis in transformed cells. However, toxicity of such compounds to slow growing normal cells is low. In addition, such analogs, like pateamine A, target translation initiation factors and are useful as anticancer and antiproliferative agents in subjects in need thereof. Moreover, the analogs, like pateamine A, are valuable molecular probes for evalutaion of eukaryotic translation initiation and as lead compounds for development of improved anticancer agents. |
| priorityDate | 2002-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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