| abstract |
The present invention relates to a compound represented by the formula: n n nwherein Ar is a phenyl group optionally having substituent(s), R 1 is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group or a heterocyclic group optionally having substituent(s), R 2 is a hydrogen atom, a C 1-6 alkyl group optionally having substituent(s) or a C 3-6 cycloalkyl group optionally having substituent(s), Z is a methylene group optionally having a C 1-6 alkyl group, ring A is a piperidine ring optionally further having substituent(s), ring B and ring C are benzene rings optionally further having substituent(s), and R 2 optionally form a ring together with the adjacent substituent on the ring B, except the compounds represented by the formula: n nor a salt thereof. The compound of the present invention has a superior tachykinin receptor antagonistic action, particularly a substance P receptor antagonistic action, and is useful as a pharmaceutical agent, for example, tachykinin receptor antagonist, an agent for the prophylaxis or treatment of lower urinary tract symptoms, gastrointestinal diseases or central nerve diseases. |