http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007149452-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc78e1b196e4cd1800b696a1c84976eb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-65 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-55 |
| filingDate | 2006-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aaf2874b1b73e0a0f226c955ad5b2b18 |
| publicationDate | 2007-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2007149452-A1 |
| titleOfInvention | Method of Treating and/or Preventing Cancers and AIDS using Sartans and/or Statins to modulate VDR, and/or PPAR, and/or GCR and/or CB1 receptors; in conjunction with certain bacteriostatic antibiotics |
| abstract | This invention is a method of killing the stealthy intra-cellular bacteria which are key to the pathogenesis of both Acquired Immune Deficiency Syndrome(s) (AIDS) and Cancers. It is currently believed that the disease(s) known as AIDS are caused by a virus, the Human Immunodeficiency Virus (HIV). But much of the long-term (chronic) destruction of the immune system in AIDS is actually caused by tiny, stealthy, antibiotic-resistant bacteria. The HIV virus weakens the immune system so that the stealthy bacteria can proliferate out-of-control, and the damage of AIDS is done just as much by these bacteria as by any virus. These very tiny L-form Cell-Wall-Deficient (CWD) antibiotic-resistant bacteria live within the cytoplasm of cells, including the phagocytic cells (e.g. monocytes, macrophages, lymphocytes, neutrophils and polymorphonuclear cells) of the immune system itself. The cellular proliferation in Cancer is catalysed the action of the same tiny L-form bacteria. They cause the cell nucleus to release mRNA signaling the Th1 cytokine cascade without the need for conventional signaling via, for example, CD4+ T-Lymphocytes. Some of these Cytokines and Chemokines, including, without limitation, Cellular Adhesion Molecule (CAM), create the environment which allows the cellular proliferation to start, and then allows the cancerous growth to gain a foothold in the body. Killing these stealthy pathogens removes the environment needed to initiate and feed the cellular proliferation commonly called ‘Cancer,’ and prevents the chronic phase of the disease AIDS. This invention achieves its objective partly by reducing the ability of these tiny L-form, intra-phagocytic bacteria to translate proteins within their 70S Ribosome. The 30S and 50S subunits of the bacterial ribosome are targeted both individually and collectively. Further, this invention activates the innate immune system with agonist(s) for the VDR Nuclear Receptor, and modulates the availability of endogenous ligands to the PPAR, GCR and CB1 receptors, conditioning the immune system to more easily recognize and kill these tiny bacterial pathogens. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10172854-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007135504-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9795601-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11389435-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013259800-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006025358-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8865749-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012082992-A1 |
| priorityDate | 2005-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 322.