| abstract |
Ornithine derivatives of the formula (I): wherein X is —CO— or —(CH 2 ) k — (wherein k is 1, 2 or 3); Y is Z-(CH 2 ) n —, and the like; {wherein Z is R 1 —CO—NR 4 —, and the like, (wherein R 1 is aryl, and the like; and R 4 is hydrogen, or lower alkyl); and n is 1, 2, 3, 4, 5 or 6}; R 2 is aryl-(lower alkyl), and the like; R 3 is -Q-R 7 , [wherein Q is —CO— or —SO 2 —, R is heterocyclyl], and the like; and R 5 and R 6 are independently hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof, which are useful as medicament. |