| abstract |
The invention provides compounds of formula (I): n nwherein: m is 0, 1 or 2; X is O, S or N—CN; R is F, Cl or CN; n A is a C 3-6 cycloalkylene group optionally substituted with a C 1-4 alkyl group; and B is a single bond or a C 1-2 alkylene group; or a pharmaceutically acceptable salt, solvate, polymorph or prodrug thereof. The compounds are PDE7 inhibitors and have a number of therapeutic applications, particularly in the treatment of pain, especially neuropathic pain. |