http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007128247-A1

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publicationDate 2007-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2007128247-A1
titleOfInvention Method for Ionically Cross-Linking Polysaccharide Material for Thin Film Applications and Products Produced Therefrom
abstract A method for producing ionically cross-linked polysaccharide material (e.g. pectin) that includes dissolving the material in a first liquid solution that includes a dissolving liquid. The first liquid solution is applied to a workpiece to form a polysaccharide-based coating on the workpiece. The coating is dried to remove a substantial portion of the dissolving liquid. Subsequent to drying, the coating is exposed to a second liquid solution that includes a compound that promotes ionic cross-linking of the polysaccharide-based coating. In the preferred embodiment, the dissolving liquid comprises water and possibly a polar solvent. The ionic cross-linking compound preferably comprises a divalent cation such as calcium (Ca 2+ ), or possibly strontium (Sr 2+ ), magnesium (Mg 2+ ), barium (Ba 2+ ), or other multivalent ions. Such a method forms a uniform ionically cross-linked film and/or coating for diverse applications, including medical devices such as implantable vascular grafts, stent-grafts and/or stents.
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